Usability of serum hedgehog signalling proteins as biomarkers in canine mammary carcinomas.

ABSTRACT:

Background

The hedgehog signalling pathway has been implicated in tumourigenesis and progression of many tumour types. This pathway has recently emerged as a therapeutic target, and inhibitors of hedgehog signalling have gained considerable attention. In dogs, the roles of hedgehog signals in several types of tumours have been investigated, but their relationship with canine mammary gland tumours (MGTs) has not been established. This study aimed to evaluate the expression of sonic hedgehog (SHH) and glioma-associated oncogene 1 (GLI-1) in the serum and mammary tumour tissues of dogs.

Results

SHH and GLI-1 protein expression levels were significantly higher in MGT tissues than in normal mammary gland tissues, as well as in malignant MGT specimens than in benign MGT specimens.

SUBMITTER: Koo H 

PROVIDER: S-EPMC10626804 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature