[¹⁸ F] -FAPI-42 PET/CT assessment of Progressive right ventricle fibrosis under pressure overload.

ABSTRACT:

Background

Right heart failure (RHF) is a complication of pulmonary hypertension (PH) and increases the mortality independently of the underlying disease. However, the process of RHF development and progression is not fully understood. We aimed to develop effective approaches for early diagnosis and precise evaluation of RHF.

Methods

Right ventricle (RV) pressure overload was performed via pulmonary artery banding (PAB) surgery in Sprague-Dawley (SD) rats to induce RHF. Echocardiography, right heart catheterization, histological staining, fibroblast activation protein (FAP) immunofluorescence and ¹⁸ F-labelled FAP inhibitor-42 ([¹⁸ F] -FAPI-42) positron emission tomography/computed tomography (PET/CT) were performed at day 3, week 1, 2, 4 and 8 after PA

SUBMITTER: Zeng X 

PROVIDER: S-EPMC10626814 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature