A systematic review and meta-analysis of the kynurenine pathway of tryptophan metabolism in rheumatic diseases.

ABSTRACT: There is an increasing interest in the pathophysiological role of the kynurenine pathway of tryptophan metabolism in the regulation of immune function and inflammation. We sought to address the link between this pathway and the presence rheumatic diseases (RD) by conducting a systematic review and meta-analysis of studies reporting the plasma or serum concentrations of tryptophan, kynurenine, and other relevant metabolites in RD patients and healthy controls. We searched electronic databases for relevant articles published between inception and the 30^th of June 2023. Risk of bias and certainty of evidence were assessed using the Joanna Briggs Institute Critical Appraisal Checklist and the Grades of Recommendation, Assessment, Development and Evaluation Working Group system. In 2

SUBMITTER: Mangoni AA 

PROVIDER: S-EPMC10626995 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature