S100 calcium-binding protein A9 promotes skin regeneration through toll-like receptor 4 during tissue expansion.

ABSTRACT:

Background

In plastic surgery, tissue expansion is widely used for repairing skin defects. However, low expansion efficiency and skin rupture caused by thin, expanded skin remain significant challenges in promoting skin regeneration during expansion. S100 calcium-binding protein A9 (S100A9) is essential in promoting wound healing; however, its effects on skin regeneration during tissue expansion remain unclear. The aim of the present study was to explore the role of S100A9 in skin regeneration, particularly collagen production to investigate its importance in skin regeneration during tissue expansion.

Methods

The expression and distribution of S100A9 and its receptors-toll-like receptor 4 (TLR-4) and receptor for advanced glycation end products were studied in expanded skin.

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC10627002 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature