Toll-Like Receptor (TLR) 1, 2, and 6 Gene Polymorphisms Support Evidence of Innate Immune Factors in Schizophrenia.

ABSTRACT:

Introduction

Schizophrenia is a complex psychiatric disorder with an important genetic contribution. Immunological abnormalities have been reported in schizophrenia. Toll-like receptor (TLR) genes play an important role in the activation of the innate immune response, which may help to explain the presence of inflammation in people with this disorder. The aim of this study was to analyze the association of TLR1, TLR2, and TLR6 gene polymorphisms in the etiology of schizophrenia.

Methods

We included 582 patients with schizophrenia and 525 healthy controls. Genetic analysis was performed using allelic discrimination with TaqMan probes.

Results

We observed significant differences between patients and controls in the genotype and allele frequencies of TLR

SUBMITTER: Sotelo-Ramirez CE 

PROVIDER: S-EPMC10627067 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature