Challenges in the Synthesis of Active Site Mimics for [NiFe]-Hydrogenases.

ABSTRACT: One of the more active areas in bioorganometallic chemistry is the preparation and reactivity studies of active site mimics of the [NiFe]-hydrogenases. One area of particular recent progress involves reactions that interconvert Ni(μ-X)Fe centers for X = OH, H, CO, as described by Song et al. Such reactions illustrate new ways to access intermediates related to the Ni-R and Ni-SI states of the enzyme. Most models are derivatives of the type (diphosphine)Ni(SR)₂Fe(CO)_3-n(PR'₃)_n. In recent work, the methodology has been generalized to include Fe^II(diphosphine) derivatives of Ni(N2S2), where N2S2^2- is the tetradentate diamine-dithiolate (CH₂N(CH₃)CH₂CH₂S^-

SUBMITTER: Basu D 

PROVIDER: S-EPMC10627515 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature