Smooth muscle cells-specific loss of OCT4 accelerates neointima formation after acute vascular injury.

ABSTRACT:

Introduction

There is growing evidence that smooth muscle cell (SMC) phenotypic transitions play critical roles during normal developmental and tissue recovery processes and in pathological conditions such as atherosclerosis. However, the molecular mechanisms responsible for these transitions are not well understood. Recently, we found that the embryonic stem cell/induced pluripotent stem cell (iPSC) factor OCT4, which was believed to be silenced in somatic cells, plays an atheroprotective role in SMC, and regulates angiogenesis after corneal alkali burn and hindlimb ischemia by mediating microvascular SMC and pericyte migration. However, the kinetics of OCT4 activation in arterial SMC and its role in acute pathological conditions are still unknown.

Methods and res

SUBMITTER: Shin J 

PROVIDER: S-EPMC10627795 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature