DNA-binding protein PfAP2-P regulates parasite pathogenesis during malaria parasite blood stages.

ABSTRACT: Malaria-associated pathogenesis such as parasite invasion, egress, host cell remodelling and antigenic variation requires concerted action by many proteins, but the molecular regulation is poorly understood. Here we have characterized an essential Plasmodium-specific Apicomplexan AP2 transcription factor in Plasmodium falciparum (PfAP2-P; pathogenesis) during the blood-stage development with two peaks of expression. An inducible knockout of gene function showed that PfAP2-P is essential for trophozoite development, and critical for var gene regulation, merozoite development and parasite egress. Chromatin immunoprecipitation sequencing data collected at timepoints matching the two peaks of pfap2-p expression demonstrate PfAP2-P binding to promoters of genes controlling trophozoite developme

SUBMITTER: Subudhi AK 

PROVIDER: S-EPMC10627835 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature