Individuals with type 2 diabetes have higher density of small intestinal neurotensin-expressing cells.

ABSTRACT: Neurotensin (NT) is a gastro-intestinal hormone involved in several pathways that regulate energy and glucose homeostasis. NT was hypothesized to act in synergy with incretin hormones to potentiate its anti-diabetic effects. Additionally, circulating NT levels were shown to rise after bariatric surgery-induced weight loss. Knowledge of NT-secreting cells distribution along the small intestine and its variation according to diabetes status could provide insights on NT role in mediating type 2 diabetes (T2D) improvement after bariatric surgery. So, our aims were to characterize NT-expressing cell distribution along the human small intestine and to compare the relative density of NT-expressing cells in the small intestine of individuals with and without T2D undergoing bariatric surgery for ob

SUBMITTER: Ferreira FP 

PROVIDER: S-EPMC10627918 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature