Effects of blood pressure and antihypertensive drugs on osteoarthritis: a mendelian randomized study.

ABSTRACT:

Background

Previous studies have suggested that antihypertensive drugs may play a role in the treatment of osteoarthritis, but these studies may be limited by confounding factors and lead to biased results. Therefore, we conducted a Mendelian randomization study to investigate the effects of blood pressure and antihypertensive drugs on osteoarthritis.

Methods

We used published large-scale genome-wide association data and applied univariate and multivariate Mendelian randomization methods. The main analysis model was inverse variance weighting, and the reliability of the results was tested using MR-Egger intercept analysis, Cochran's Q test, and leave-one-out analysis. We comprehensively evaluated the relationship between systolic blood pressure, diastolic blood pressure, 12

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC10627939 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature