Resting heart rate, cognitive function, and inflammation in older adults: a population-based study.

ABSTRACT:

Background

Emerging evidence has linked elevated resting heart rate (RHR) with poor cognitive function in older adults, but the mechanisms underlying their association are poorly understood.

Methods

This population-based cross-sectional study included 4510 dementia-free participants (age ≥ 65 years; 56.9% females; 38.3% no formal education) in the baseline examination of the Multidomain Interventions to Delay Dementia and Disability in Rural China study. Of these, 1,386 had data on serum proinflammatory cytokines and adhesion molecules. RHR was measured using 12-lead electrocardiograph. We used the Mini-Mental State Examination (MMSE) and a neuropsychological test battery to assess cognitive function. Data were analyzed using the general linear and restricted cubic splines m

SUBMITTER: Mao M 

PROVIDER: S-EPMC10628022 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature