The role of the transsulfuration pathway in spermatogenesis of vitamin D deficient mice.

ABSTRACT: Vitamin D deficiency is a global health problem and has been linked to defective spermatogenesis and male infertility. In this study, we aimed to investigate the main enzymes involved in the transsulfuration pathway of 1-carbon metabolism, and spermatogenesis function. Therefore, sixteen male C57 mice were addressed to a control (standard diet) or vitamin D deficient (VDD) diet for 14 weeks. The results show that compared to the standard diet, VDD increased final body weight and reduced sperm quality, caused damage to the testicular structure, and decreased the serum levels of testosterone. In addition, serum concentrations of homocysteine, vitamin B12, and sperm oxidative stress markers increased. In testicular tissues, the CBS and CSE protein levels were down-regulated whereas HO-1 was u

SUBMITTER: Jamshidian-Ghalehsefidi N 

PROVIDER: S-EPMC10628119 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature