Eco-evolutionary feedbacks in the human gut microbiome.

ABSTRACT: Gut microbiota can evolve within their hosts on human-relevant timescales, but little is known about how these changes influence (or are influenced by) the composition of their local community. Here, by combining ecological and evolutionary analyses of a large cohort of human gut metagenomes, we show that the short-term evolution of the microbiota is linked with shifts in its ecological structure. These correlations are not simply explained by expansions of the evolving species, and often involve additional fluctuations in distantly related taxa. We show that similar feedbacks naturally emerge in simple resource competition models, even in the absence of cross-feeding or predation. These results suggest that the structure and function of host microbiota may be shaped by their local evoluti

SUBMITTER: Good BH 

PROVIDER: S-EPMC10628149 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature