Prognostic and immunotherapeutic significance of immunogenic cell death-related genes in colon adenocarcinoma patients.

ABSTRACT: In recent years, genes associated with immunogenic cell death (ICD)-related genes have garnered significant interest as potential targets for immunotherapy. As a frontier in cancer treatment, immunotherapy has notably enhanced the therapeutic outcomes for cancer patients. However, since only a subset of patients benefits from this treatment approach, there is an imperative need for biomarker research to enhance patient sensitivity to immunotherapy. Expression of ICD-related genes and clinical patient data were sourced from The Cancer Genome Atlas (TCGA) database. Utilizing univariate Cox regression analysis, we constructed a signature for predicting the overall survival of colon adenocarcinoma (COAD) patients. A genomic feature analysis was performed, incorporating tumor mutation burden (T

SUBMITTER: Xu J 

PROVIDER: S-EPMC10628212 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature