Prognostic value and immune landscapes of immunogenic cell death-associated lncRNAs in lung adenocarcinoma.

ABSTRACT: Immunogenic cell death (ICD) has been demonstrated to activate T cells to kill tumor cells, which is closely related to tumor development, and long noncoding RNAs (lncRNAs) are also involved. However, it is not known whether ICD-related lncRNAs are associated with the development of lung adenocarcinoma (LUAD). We downloaded ICD-related genes from GeneCards and the transcriptome statistics of LUAD patients from The Cancer Genome Atlas (TCGA) and subsequently developed and verified a predictive model. A successful model was used together with other clinical features to construct a nomogram for predicting patient survival. To further study the mechanism of tumor action and to guide therapy, we performed enrichment analysis, tumor microenvironment analysis, somatic mutation analysis, drug sens

SUBMITTER: Shu K 

PROVIDER: S-EPMC10628222 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature