Identifying actionable druggable targets for breast cancer: Mendelian randomization and population-based analyses.

ABSTRACT:

Background

Drug repurposing provides a cost-effective approach to address the need for breast cancer prevention and therapeutics. We aimed to identify actionable druggable targets using Mendelian randomization (MR) and then validate the candidate drugs using population-based analyses.

Methods

We identified genetic instruments for 1406 actionable targets of approved non-oncological drugs based on gene expression, DNA methylation, and protein expression quantitative trait loci (eQTL, mQTL, and pQTL, respectively). Genome-wide association study (GWAS) summary statistics were obtained from the Breast Cancer Association Consortium (122,977 cases, 105,974 controls). We further conducted a nested case-control study using data retrieved from Swedish registers to validate the candida

SUBMITTER: Zhang N 

PROVIDER: S-EPMC10628347 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature