Trajectories of olfactory identification preceding incident mild cognitive impairment and dementia: a longitudinal study.

ABSTRACT:

Background

The pattern of olfactory identification change in the early phases of dementing disorders is unclear. We aimed to assess olfactory identification trajectories preceding incident mild cognitive impairment (MCI) and dementia and explore the role of brain pathologies in these trajectories.

Methods

Within the Rush Memory and Aging Project, 1318 dementia-free older adults were followed annually for up to 11 years. Olfactory identification was assessed using the Brief Smell Identification Test annually. Of 900 cognitively intact participants, incident MCI and dementia were diagnosed following standard criteria. Over follow-up, 518 participants died and underwent brain autopsies for neuropathological assessment. Data were analyzed using mixed-effect models with backward

SUBMITTER: Guo J 

PROVIDER: S-EPMC10628348 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature