Serum and follicular fluid metabolome and markers of ovarian stimulation.

ABSTRACT:

Study question

What metabolic pathways and metabolites in the serum and follicular fluid are associated with peak estradiol levels and the number of mature oocytes?

Summary answer

In the serum metabolome, mostly fatty acid and amino acid pathways were associated with estradiol levels and mature oocytes while in the follicular fluid metabolome, mostly lipid, vitamin, and hormone pathways were associated with peak estradiol levels and mature oocytes.

What is known already

Metabolomics has identified several metabolic pathways and metabolites associated with infertility but limited data are available for ovarian stimulation outcomes.

Study design, size, duration

A prospective cohort study of women undergoing IVF from 2009 to 2015.

Participants/materials, settin

SUBMITTER: Hood RB 

PROVIDER: S-EPMC10628502 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature