Metabolomics analysis of human cumulus cells obtained from cumulus-oocyte complexes with different developmental potential.

ABSTRACT:

Study question

Is the abundance of certain biochemical compounds in human cumulus cells (CCs) related to oocyte quality?

Summary answer

Malonate, 5-oxyproline, and erythronate were positively associated with pregnancy potential.

What is known already

CCs are removed and discarded prior to ICSI, thereby constituting an interesting biological material on which to perform molecular analysis aimed to predict oocyte developmental competence. Mitochondrial DNA content and transcriptional analyses in CC have been shown to provide a poor predictive value of oocyte competence, but the untargeted analysis of biochemical compounds (metabolomics) has been unexplored.

Study design, size, duration

CCs were obtained from three groups of cumulus-oocyte complexes (COCs) of know

SUBMITTER: Martinez-Moro A 

PROVIDER: S-EPMC10628504 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature