Associations of genetically predicted circulating levels of cytokines with telomere length: a Mendelian randomization study.

ABSTRACT:

Background

Telomere length (TL) has been regarded as a biomarker of aging, and TL shortening is associated with numerous chronic illnesses. The mounting evidence has shown that inflammatory cytokines are involved in maintaining or shortening TL, the causality of cytokines with TL remains unknown. Therefore, we performed a two-sample Mendelian randomization (MR) analysis to estimate the underlying correlations of circulating inflammatory cytokines with TL.

Methods

Genetic instrumental variables for inflammatory cytokines were identified through a genome-wide association study (GWAS) involving 8,293 European individuals. Summary statistics of TL were derived from a UK Bio-bank cohort comprising 472,174 samples of individuals with European descent. We employed the inverse-varia

SUBMITTER: Pan R 

PROVIDER: S-EPMC10628532 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature