Differential early response of monocyte/macrophage subsets to intra-operative corticosteroid administration in lung transplantation.

ABSTRACT:

Introduction

Lung transplantation often results in primary and/or chronic dysfunctions that are related to early perioperative innate allo-responses where myeloid subsets play a major role. Corticosteroids are administered upon surgery as a standard-of-care but their action on the different myeloid cell subsets in that context is not known.

Methods

To address this issue, we used a cross-circulatory platform perfusing an extracorporeal lung coupled to cell mapping in the pig model, that enabled us to study the recruited cells in the allogeneic lung over 10 hours.

Results

Myeloid cells, i.e. granulocytes and monocytic cells including classical CD14^pos and non-classical/intermediate CD16^pos cells, were the dominantly recruited subsets, with the latt

SUBMITTER: Glorion M 

PROVIDER: S-EPMC10628533 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature