Sublobar resection reduces the risk of postoperative cognitive dysfunction compared with lobectomy.

ABSTRACT:

Objectives

Sublobar resection, including wedge resection and segmentectomy, is non-inferior to lobectomy in early-stage non-small cell lung cancer treatment. We aimed to compare the risk of postoperative cognitive dysfunction (POCD) between sublobar resection and lobectomy.

Methods

We conducted a prospective cohort study. Patients with sublobar resection or lobectomy were divided into the sublobar group or the lobar group, respectively. Cognition was assessed before and after surgery with Montreal Cognitive Assessment and Minimum Mental State Examination tests. POCD is defined as Z score of Montreal Cognitive Assessment change ≤-1.96. Propensity score matching (PSM) was performed to make demographics well-balanced between the 2 groups.

Results

A total of 335 patients

SUBMITTER: Zang N 

PROVIDER: S-EPMC10628534 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature