Identification of Immune Subtypes and Candidate mRNA Vaccine Antigens in Small Cell Lung Cancer.

ABSTRACT:

Background

Immune checkpoint inhibitors (ICIs) have demonstrated promising outcomes in small cell lung cancer (SCLC), but not all patients benefit from it. Thus, developing precise treatments for SCLC is a particularly urgent need. In our study, we constructed a novel phenotype for SCLC based on immune signatures.

Methods

We clustered patients with SCLC hierarchically in 3 publicly available datasets according to the immune signatures. ESTIMATE and CIBERSORT algorithm were used to evaluate the components of the tumor microenvironment. Moreover, we identified potential mRNA vaccine antigens for patients with SCLC, and qRT-PCR were performed to detect the gene expression.

Results

We identified 2 SCLC subtypes and named Immunity High (Immunity_H) and Immunity Low (Immuni

SUBMITTER: Wei Y 

PROVIDER: S-EPMC10628581 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature