Modulation of recovery from neonatal hyperoxic lung injury by sex as a biological variable.

ABSTRACT: Recovery from lung injury during the neonatal period requires the orchestration of many biological pathways. The modulation of such pathways can drive the developing lung towards proper repair or persistent maldevelopment that can lead to a disease phenotype. Sex as a biological variable can regulate these pathways differently in the male and female lung exposed to neonatal hyperoxia. In this study, we assessed the contribution of cellular diversity in the male and female neonatal lung following injury. Our objective was to investigate sex and cell-type specific transcriptional changes that drive repair or persistent injury in the neonatal lung and delineate the alterations in the immune-endothelial cell communication networks using single cell RNA sequencing (sc-RNAseq) in a murine model

SUBMITTER: Cantu A 

PROVIDER: S-EPMC10628633 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature