Similar adverse outcome rates with high or low oxygen saturation targets in an area with low background mortality.

ABSTRACT:

Background

Randomized controlled trials have indicated reduced mortality rates in very preterm infants assigned to high compared to low oxygen saturation (SpO₂) target levels, accompanied by higher rates of retinopathy of prematurity and bronchopulmonary dysplasia. However, the benefit-to-harm ratio may depend on the local background mortality risk. We therefore aimed to quantify the risk-benefit ratios of different SpO₂ target ranges in 10 tertiary newborn intensive care units (NICUs) in East Germany.

Methods

In a retrospective multicenter study, 1,399 infants born between 2008 and 2012 at a gestational age between 24 0/7 and 27 6/7 weeks and with a birthweight below 1,250 g were grouped according to the hospital's target SpO₂ range [high ox

SUBMITTER: Willgerodt N 

PROVIDER: S-EPMC10628636 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature