N-acetylcysteine attenuates the incidence of phlebitis induced by carbomer/vinorelbine gel.

ABSTRACT:

Background

The high incidence and severe clinical manifestations of phlebitis pose a complex and urgent clinical challenge. The rapid and simple establishment of animal phlebitis models and the development of preventive strategies are crucial to resolving this problem.

Methods

In this study, we established such models by mixing vinorelbine ditartrate (VNR) and carbomer to form a sustained-release gel carrier, and then injected it around the veins rather than inside the vessels. Furthermore, we analyzed the efficacy of the carbomer/VNR gel in inducing phlebitis by monitoring the morphology of the veins using HE staining, immunohistochemical and immunofluorescence staining, and western blotting. Reactive oxygen species (ROS) and lipid peroxidation levels were determined using

SUBMITTER: Zhang H 

PROVIDER: S-EPMC10628679 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature