Apolipoprotein B and interleukin 1 receptor antagonist: reversing the risk of coronary heart disease.

ABSTRACT:

Aims

Epidemiological evidence for the link of interleukin 1 (IL-1) and its inhibition with cardiovascular diseases (CVDs) remains controversial. We aim to investigate the cardiovascular effects of IL-1 receptor antagonist (IL-1Ra) and underlying mechanisms.

Methods

Genetic variants identified from a genome-wide association study involving 30,931 individuals were used as instrumental variables for the serum IL-1Ra concentrations. Genetic associations with CVDs and cardiometabolic risk factors were obtained from international genetic consortia. Inverse-variance weighted method was utilized to derive effect estimates, while supplementary analyses employing various statistical approaches.

Results

Genetically determined IL-1Ra level was associated with increased risk of co

SUBMITTER: Yang F 

PROVIDER: S-EPMC10628700 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature