Genome-wide transcription landscape of citric acid producing Aspergillus niger in response to glucose gradient.

ABSTRACT: Aspergillus niger is the main industrial workhorse for global citric acid production. This fungus has complex sensing and signaling pathways to respond to environmental nutrient fluctuations. As the preferred primary carbon source, glucose also acts as a critical signal to trigger intracellular bioprocesses. Currently, however, there is still a knowledge gap in systems-level understanding of metabolic and cellular responses to this vital carbon source. In this study, we determined genome-wide transcriptional changes of citric acid-producing Aspergillus niger in response to external glucose gradient. It demonstrated that external glucose fluctuation led to transcriptional reprogramming of many genes encoding proteins involved in fundamental cellular process, including ribosoma

SUBMITTER: Zheng X 

PROVIDER: S-EPMC10628723 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature