Neighborhood Deprivation and DNA Methylation and Expression of Cancer Genes in Breast Tumors.

ABSTRACT:

Importance

The biological processes that underlie the association of neighborhood environment with chronic diseases, such as cancer, remain poorly understood.

Objective

To determine whether differences in breast tissue DNA methylation are associated with neighborhood deprivation among Black and White women with breast cancer.

Design, setting, and participants

This cross-sectional study collected breast tissue from women undergoing surgery for breast cancer between January 1, 1993, and December 31, 2003. Participants were recruited through the University of Maryland Medical Center, with additional collection sites at Baltimore-area hospitals. Data analysis was performed from March 1 through December 1, 2022.

Exposure

Year 2000 census tract-level socioeconomic de

SUBMITTER: Jenkins BD 

PROVIDER: S-EPMC10628736 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature