Integrated Immunopeptidomic and Proteomic Analysis of COVID-19 lung biopsies.

ABSTRACT:

Introduction

Severe respiratory illness is the most prominent manifestation of patients infected with SARS-CoV-2, and yet the molecular mechanisms underlying severe lung disease in COVID-19 affected patients still require elucidation. Human leukocyte antigen class I (HLA-I) expression is crucial for antigen presentation and the host's response to SARS-CoV-2.

Methods

To gain insights into the immune response and molecular pathways involved in severe lung disease, we performed immunopeptidomic and proteomic analyses of lung tissues recovered at four COVID-19 autopsy and six non-COVID-19 transplants.

Results

We found signals of tissue injury and regeneration in lung fibroblast and alveolar type I/II cells, resulting in the production of highly immunogenic self-antigens w

SUBMITTER: Yin S 

PROVIDER: S-EPMC10628763 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature