Development of a new travellers' diarrhoea clinical severity classification and its utility in confirming rifamycin-SV efficacy.

ABSTRACT:

Background

travellers' diarrhoea (TD) is frequently reported with incidence up to 40% in high-risk destinations. Previous studies showed that the number of loose stools alone is inadequate to holistically predict the severity of TD. To improve the prediction of prognosis and to optimize treatments, a simple risk-based clinical severity classification has been developed.

Methods

pooled baseline data of signs and symptoms and number of loose stools from 1098 subjects enrolled in two double-blind Phase 3 trials of rifamycin-SV were analyzed with correlation, multiple correspondence analyses, prognostic factor criteria, and Contal and O'Quigley method to generate a TD severity classification (mild, moderate and severe). The relative importance of this classification on resolutio

SUBMITTER: DuPont HL 

PROVIDER: S-EPMC10628770 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature