Glycemic Outcomes of Hospitalized Patients on Ambulatory Humulin-R U-500 Insulin.

ABSTRACT:

Objective

Managing hospitalized patients on ambulatory U-500 insulin is challenging because of limited guidance on how to safely adjust insulin doses during admission. We sought to evaluate glycemic outcomes in relation to inpatient insulin doses in patients receiving U-500 prior to hospitalization.

Methods

Retrospective study of hospitalized patients on ambulatory U-500 seen consecutively from January 2015 to December 2019. Primary outcomes were inpatient hypoglycemia, hyperglycemia, and normoglycemia at different insulin dosages expressed as weight-based (unit/kg/d) inpatient total daily dose (TDD) and ratio of inpatient to outpatient TDD.

Results

We identified 66 admissions of 46 unique patients. The median (interquartile range) body mass index was 41.0 kg/m^2<

SUBMITTER: Kanbour S 

PROVIDER: S-EPMC10628779 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature