Multivariable Model to Predict an ACTH Stimulation Test to Diagnose Adrenal Insufficiency Using Previous Test Results.

ABSTRACT:

Context

The adrenocorticotropin hormone stimulation test (AST) is used to diagnose adrenal insufficiency, and is often repeated in patients when monitoring recovery of the hypothalamo-pituitary-adrenal axis.

Objective

To develop and validate a prediction model that uses previous AST results with new baseline cortisol to predict the result of a new AST.

Methods

This was a retrospective, longitudinal cohort study in patients who had undergone at least 2 ASTs, using polynomial regression with backwards variable selection, at a Tertiary UK adult endocrinology center. Model was developed from 258 paired ASTs over 5 years in 175 adults (mean age 52.4 years, SD 16.4), then validated on data from 111 patients over 1 year (51.8, 17.5) from the same center, data collected after

SUBMITTER: Lawrence NR 

PROVIDER: S-EPMC10628819 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature