Neurofilament Light Chain Elevation and Disability Progression in Multiple Sclerosis.

ABSTRACT:

Importance

Mechanisms contributing to disability accumulation in multiple sclerosis (MS) are poorly understood. Blood neurofilament light chain (NfL) level, a marker of neuroaxonal injury, correlates robustly with disease activity in people with MS (MS); however, data on the association between NfL level and disability accumulation have been conflicting.

Objective

To determine whether and when NfL levels are elevated in the context of confirmed disability worsening (CDW).

Design, setting, and participants

This study included 2 observational cohorts: results from the Expression, Proteomics, Imaging, Clinical (EPIC) study at the University of California San Francisco (since 2004) were confirmed in the Swiss Multiple Sclerosis Cohort (SMSC), a multicenter study in 8 cent

SUBMITTER: Abdelhak A 

PROVIDER: S-EPMC10628837 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature