APOE Genotype and Alzheimer Disease Risk Across Age, Sex, and Population Ancestry.

ABSTRACT:

Importance

Apolipoprotein E (APOE)*2 and APOE*4 are, respectively, the strongest protective and risk-increasing, common genetic variants for late-onset Alzheimer disease (AD), making APOE status highly relevant toward clinical trial design and AD research broadly. The associations of APOE genotypes with AD are modulated by age, sex, race and ethnicity, and ancestry, but these associations remain unclear, particularly among racial and ethnic groups understudied in the AD and genetics research fields.

Objective

To assess the stratified associations of APOE genotypes with AD risk across sex, age, race and ethnicity, and global population ancestry.

Design, setting, participants

This genetic association study included case-control, family-based, population-based, and longi

SUBMITTER: Belloy ME 

PROVIDER: S-EPMC10628838 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature