ApoE4 and Connectivity-Mediated Spreading of Tau Pathology at Lower Amyloid Levels.

ABSTRACT:

Importance

For the Alzheimer disease (AD) therapies to effectively attenuate clinical progression, it may be critical to intervene before the onset of amyloid-associated tau spreading, which drives neurodegeneration and cognitive decline. Time points at which amyloid-associated tau spreading accelerates may depend on individual risk factors, such as apolipoprotein E ε4 (ApoE4) carriership, which is linked to faster disease progression; however, the association of ApoE4 with amyloid-related tau spreading is unclear.

Objective

To assess if ApoE4 carriers show accelerated amyloid-related tau spreading and propose amyloid positron emission tomography (PET) thresholds at which tau spreading accelerates in ApoE4 carriers vs noncarriers.

Design, setting, and participants

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SUBMITTER: Steward A 

PROVIDER: S-EPMC10628846 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature