Detecting and differentiating neurotransmitters using ultraviolet plasmonic engineered native fluorescence.

ABSTRACT: Detecting neurotransmitters with high sensitivity and selectivity is important to understand their roles in biological functions. Current detection methods for neurotransmitters suffer from poor sensitivity or selectivity. In this article, we propose ultraviolet (UV) plasmonic engineered native fluorescence as a new sensing mechanism to detect neurotransmitters with high sensitivity and selectivity. We measured the native fluorescence of three monoamine neurotransmitters, dopamine (DA), norepinephrine (NE), and 3,4-dihydroxyphenylacetic acid (DOPAC). The average net enhancement and total photon yield enhancement on an aluminum hole array with 300 nm hole spacing substrate were found to be 50× and 60×, for the three molecules. We also observed a 1.5-1.7× reduction in the dominant photon ble

SUBMITTER: Lee JY 

PROVIDER: S-EPMC10628848 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature