A tumor microenvironment-responsive microneedle patch for chemodynamic therapy of oral squamous cell carcinoma.

ABSTRACT: Oral squamous cell carcinoma (OSCC) is one of the most common malignant tumors of the head and neck, and this disease has become a threat to public health due to its poor prognosis and high fatality rate. Chemodynamic therapy (CDT) is an emerging oncology treatment based on the Fenton reaction. However, the lack of endogenous hydrogen peroxide (H₂O₂) in tumor cells and the high concentration of glutathione (GSH) that depletes toxic hydroxyl radicals (·OH) significantly impair the efficacy of CDT. Here, we developed a polyvinyl alcohol (PVA)-based soluble microneedle patch (denoted as Fe₃O₄ + VC-MN) loaded with Fe₃O₄ nanoparticles (NPs) and vitamin C (VC) for the effective treatment of OSCC. When Fe₃O₄ +

SUBMITTER: Zhao S 

PROVIDER: S-EPMC10629002 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature