Causal effects of genetically vitamins and sepsis risk: a two-sample Mendelian randomization study.

ABSTRACT:

Background

In recent years, observational studies have been conducted to investigate the potential impact of vitamins on sepsis. However, many of these studies have produced inconsistent results. Our Mendelian randomization (MR) study aims to evaluate the causality between vitamins and sepsis from a genetic perspective.

Methods

Our MR study was designed following the STROBE-MR guidelines. Genetic instrumental variables for vitamins including folate, vitamin B12, B6, A (Retinol), C, D, and K were obtained from previous genome-wide association studies (GWAS) and MR studies. Five different sepsis severity levels were included in the analysis. The genetic instrumental variables were screened for potential confounders using PhenoScanner V2. MR analysis was performed using MR-egge

SUBMITTER: Lou C 

PROVIDER: S-EPMC10629037 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature