Proteomic biomarkers for survival in systemic sclerosis-associated pulmonary hypertension.

ABSTRACT:

Background

Interstitial lung disease (ILD) and pulmonary hypertension (PH) represent the major causes of mortality in systemic sclerosis (SSc). Patients with systemic sclerosis and combined PH and ILD (SSc-PH-ILD) generally have a poor prognosis. Predictors of survival and of potential benefit of treatment are lacking in patients with SSc-PH-ILD.

Objective

To identify specific plasma protein expression patterns associated with survival in patients with SSc-PH-ILD.

Materials and methods

Post-hoc analysis of a prospective multicenter French study in patients with PH-ILD. An untargeted proteomic analysis using mass spectrometry was performed to identify plasma protein changes associated with long-term overall survival in patients with SSc-PH-ILD.

Results

Thirty tw

SUBMITTER: Mismetti V 

PROVIDER: S-EPMC10629050 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature