SHMT2 regulates esophageal cancer cell progression and immune Escape by mediating m6A modification of c-myc.

ABSTRACT:

Background

In recent years, the role of altered cellular metabolism in tumor progression has attracted widespread attention. Related metabolic enzymes have also been considered as potential cancer therapeutic targets. Serine hydroxymethyltransferase 2 (SHMT2) has been reported to be upregulated in several cancers and associated with poor prognosis. However, there are few studies of SHMT2 in esophageal cancer (EC), and the related functions and mechanisms also need to be further explored.

Methods

In this study, we first analyzed SHMT2 expression in EC by online database and clinical samples. Then, the biological functions of SHMT2 in EC were investigated by cell and animal experiments. The intracellular m6A methylation modification levels were also evaluated by MeRIP. Linked

SUBMITTER: Qiao Z 

PROVIDER: S-EPMC10629073 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature