Diallyl trisulfide improves spinal cord ischemia-reperfusion injury damage by activating AMPK to stabilize mitochondrial function.

ABSTRACT:

Background

Spinal cord ischemia-reperfusion injury (SCII) is a catastrophic event, which can cause paraplegia in severe cases. In the reperfusion stage, oxidative stress was up-regulated, which aggravated the injury and apoptosis of neurons. As the main active ingredient of garlic, diallyl trisulfide (DATS) displays strong antioxidant capacity. However, it is unknown whether DATS can protect the neurons of SCII.

Materials and methods

In this study, the descending aorta at the distal end of the left subclavian artery was ligated and perfused again after 14 min. Samples including blood and spinal cord (L2-L5) were taken 24 h later for morphological and biochemical examination.

Results

After SCII, the rats showed motor dysfunction, increase apoptosis, malondialdehyde con

SUBMITTER: Sun Y 

PROVIDER: S-EPMC10629077 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature