Causal relationship between gut microbiota and myasthenia gravis: a bidirectional mendelian randomization study.

ABSTRACT:

Background

Observational studies have demonstrated an association between gut microbiota and myasthenia gravis; however, the causal relationship between the two still lacks clarity. Our goals are to ascertain the existence of a bidirectional causal relationship between gut microbiota composition and myasthenia gravis, and to investigate how gut microbiota plays a role in reducing the risk of myasthenia gravis.

Methods

We acquired gut microbiota data at the phylum, class, order, family, and genus levels from the MiBioGen consortium (N = 18,340) and myasthenia gravis data from the FinnGen Research Project (426 cases and 373,848 controls). In the two-sample Mendelian randomization analysis, we assessed the causal relationship between the gut microbiota and myasthenia gravis. We

SUBMITTER: Su T 

PROVIDER: S-EPMC10629094 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature