Effect on capillary refill time of volume expansion and increase of the norepinephrine dose in patients with septic shock.

ABSTRACT:

Background

Capillary refill time (CRT) has been suggested as a variable to follow during the course of septic shock. We systematically investigated the effects on CRT of volume expansion and norepinephrine.

Methods

In 69 septic shock patients, we recorded mean arterial pressure (MAP), cardiac index (CI), and 5 consecutive CRT measurements (video method, standardized pressure applied on the fingertip) before and after a 500-mL saline infusion in 33 patients and before and after an increase of the norepinephrine dose in 36 different patients. Fluid responders were defined by an increase in CI ≥ 15%, and norepinephrine responders by an increase in MAP ≥ 15%.

Results

The least significant change of CRT was 23%, so that changes in CRT were considered significant if larger

SUBMITTER: Fage N 

PROVIDER: S-EPMC10629142 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature