Tau reduction attenuates autism-like features in Fmr1 knockout mice.

ABSTRACT:

Background

Fragile X syndrome (FXS) is a leading cause of autism spectrum disorder (ASD) and resulted from a loss of the FMR1-encoded fragile X messenger ribonucleoprotein 1 (FMRP) protein due to large CGG repeat expansions in the promoter region of the FMR1 gene. The microtubule-associated protein Tau is a promising target for Tauopathic diseases and our preliminary study found that Tau protein levels were increased in the brain of Fmr1 knockout (KO) mice, a model of FXS. However, whether Tau reduction can prevent autism-like features in Fmr1 KO mice and become a novel strategy for FXS treatment remain unknown.

Methods

Tau was genetically reduced in Fmr1 KO mice through crossing Fmr1^± female mice with Mapt^± male mice. The male offspring with different

SUBMITTER: Zhao S 

PROVIDER: S-EPMC10629153 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature