Baseline and interim [18F]FDG-PET/MRI to assess treatment response and survival in patients with M0 esophageal squamous cell carcinoma treated by curative-intent therapy.

ABSTRACT:

Background

To investigate the value of [18F]FDG-PET/MRI in predicting treatment response and survival in patients with primary M0 esophageal squamous cell carcinoma.

Methods

Patients with esophageal squamous cell carcinoma received [18F]FDG-PET/MRI at baseline and during neoadjuvant or definitive chemoradiotherapy. The treatment response was classified according to the Response Evaluation Criteria for Solid Tumors 1.1. We used Kaplan-Meier and Cox regression analyses to assess the association between PET/MRI parameters and overall survival (OS) or progression-free survival (PFS).

Results

We included 40 M0 patients in the final analysis. The volume transfer constant (K^trans) from baseline PET/MRI (area under the curve (AUC) = 0.688, P = 0.034) and total lesi

SUBMITTER: Chao YK 

PROVIDER: S-EPMC10629192 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature