Inflammation and altered metabolism impede efficacy of functional electrical stimulation in critically ill patients.

ABSTRACT:

Background

Critically ill patients suffer from acute muscle wasting, which is associated with significant physical functional impairment. We describe data from nested muscle biopsy studies from two trials of functional electrical stimulation (FES) that did not shown improvements in physical function.

Methods

Primary cohort: single-centre randomized controlled trial. Additional healthy volunteer data from patients undergoing elective hip arthroplasty. Validation cohort: Four-centre randomized controlled trial.

Intervention

FES cycling for 60-90min/day.

Analyses

Skeletal muscle mRNA expression of 223 genes underwent hierarchal clustering for targeted analysis and validation.

Results

Positively enriched pathways between healthy volunteers and ICU participan

SUBMITTER: Jameson TSO 

PROVIDER: S-EPMC10629203 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature