ATM inhibition blocks glucose metabolism and amplifies the sensitivity of resistant lung cancer cell lines to oncogene driver inhibitors.

ABSTRACT:

Background

ATM is a multifunctional serine/threonine kinase that in addition to its well-established role in DNA repair mechanisms is involved in a number of signaling pathways including regulation of oxidative stress response and metabolic diversion of glucose through the pentose phosphate pathway. Oncogene-driven tumorigenesis often implies the metabolic switch from oxidative phosphorylation to glycolysis which provides metabolic intermediates to sustain cell proliferation. The aim of our study is to elucidate the role of ATM in the regulation of glucose metabolism in oncogene-driven cancer cells and to test whether ATM may be a suitable target for anticancer therapy.

Methods

Two oncogene-driven NSCLC cell lines, namely H1975 and H1993 cells, were treated with ATM inhibito

SUBMITTER: Terlizzi C 

PROVIDER: S-EPMC10629204 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature