Predictive analytics identifies key factors driving hyperalgesic priming of muscle sensory neurons.

ABSTRACT: Hyperalgesic priming, a form of neuroplasticity induced by inflammatory mediators, in peripheral nociceptors enhances the magnitude and duration of action potential (AP) firing to future inflammatory events and can potentially lead to pain chronification. The mechanisms underlying the development of hyperalgesic priming are not well understood, limiting the identification of novel therapeutic strategies to combat chronic pain. In this study, we used a computational model to identify key proteins whose modifications caused priming of muscle nociceptors and made them hyperexcitable to a subsequent inflammatory event. First, we extended a previously validated model of mouse muscle nociceptor sensitization to incorporate Epac-mediated interaction between two G protein-coupled receptor signalin

SUBMITTER: Nagaraja S 

PROVIDER: S-EPMC10629345 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature