Population-specific Mutation Patterns in Breast Tumors from African American, European American, and Kenyan Patients.

ABSTRACT: Women of African descent have the highest breast cancer mortality in the United States and are more likely than women from other population groups to develop an aggressive disease. It remains uncertain to what extent breast cancer in Africa is reminiscent of breast cancer in African American or European American patients. Here, we performed whole-exome sequencing of genomic DNA from 191 breast tumor and non-cancerous adjacent tissue pairs obtained from 97 African American, 69 European American, 2 Asian American, and 23 Kenyan patients. Our analysis of the sequencing data revealed an elevated tumor mutational burden in both Kenyan and African American patients, when compared with European American patients. TP53 mutations were most prevalent, particularly in African American patients, follo

SUBMITTER: Tang W 

PROVIDER: S-EPMC10629394 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature